![]() The lifetime risk of developing ALS in the Irish population is 2.88 and 2.29 per 1,000 men and women respectively, corresponding to 1 in 347 men and 1 in 436 women. Using data from the Irish ALS register, between 20, we calculated 1) age-adjusted lifetime risks of developing ALS, 2) ALS concordance rates in parent-offspring pairs and 3) overall and sex-specific ALS heritability estimates.ġ117 Irish patients with ALS were included in the study. To determine the heritability of Amyotrophic Lateral Sclerosis (ALS). To resolve this question, we have conducted the largest population-based study of ALS heritability to date. ALS is known to be of complex genetic origin, but the heritability of the disease remains unclear. Heritability describes the proportion of risk of developing a condition that is explained by genetic factors. We’re experiencing unusually high levels of traffic. The latest research and news affecting neurology.A network of 36,000+ neurologists and neuroscience professionals.Guidelines and publications including Neurology® journal.Discounts on Annual Meeting registration.Online education resources at no additional cost.Become a Memberīy becoming a member of the AAN, you can receive exclusive information to help you at every stage of your career. Log In Email or 6-digit member ID Password Remember me Forgot Password? Log In Get tools and information for your specific career stage and professional needs. ![]()
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